Article
Multiple sclerosis: MHC associations and therapeutic implications.
Expert reviews in molecular medicine - 14 Feb 2005
Holmes Samantha, Friese Manuel A, Siebold Christian, Jones E Yvonne, Bell John, Fugger Lars
Abstract excerpt
Multiple sclerosis (MS) is an autoimmune disease with an important genetic component. The strongest genetic association is with the major histocompatibility complex (MHC) region. Several MHC alleles predispose to the disease, the most prominent of which are certain alleles in the HLA-DR2 haplotype. Functional and structural studies have helped to explain the molecular basis of these associations. Although there...
Topics
- Animals
- Autoantigens
- CD4-Positive T-Lymphocytes
- Disease Models, Animal
- Genetic Predisposition to Disease
- HLA-DR2 Antigen
- Haplotypes
- Humans
- Immunologic Factors
- Immunosuppressive Agents
- Immunotherapy