Article
The association of glutathione S-transferase T1 and M1 deletions with myocardial infarction.
Free radical research - 1 Mar 2021
Zivkovic Maja, Bubic Maja, Kolakovic Ana, Dekleva Milica, Stankovic Goran, Stankovic Aleksandra, Djuric Tamara
Abstract excerpt
Glutathione S-transferases (GSTs) are the family of enzymes involved in the second line of defense against oxidative stress (OS). The lack of GSTT1/GSTM1 enzyme quantity or activity, due to the presence of homozygous deletion compromises antioxidative defense resulting in OS. OS is the critical mechanism in the pathophysiology of atherosclerosis, coronary artery disease, and myocardial infarction (MI). The...
Topics
- Female
- Genetic Predisposition to Disease
- Glutathione Transferase
- Humans
- Male
- Middle Aged
- Myocardial Infarction
- Prospective Studies
- Risk Factors
- Sequence Deletion