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Mutational burden, MHC-I expression and immune infiltration as limiting factors for in situ vaccination by TNFα and IL-12 gene electrotransfer.

Bioelectrochemistry (Amsterdam, Netherlands) - 1 Aug 2021

Kamensek Urska, Ursic Katja, Markelc Bostjan, Cemazar Maja, Setrajcic Dragos Vita, Sersa Gregor

Abstract excerpt

In situ vaccination is a promising immunotherapeutic approach, where various local ablative therapies are used to induce an immune response against tumor antigens that are released from the therapy-killed tumor cells. We recently proposed using intratumoral gene electrotransfer for concomitant transfection of a cytotoxic cytokine tumor necrosis factor-α (TNFα) to induce in situ vaccination, and an...

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PMID: 33991775
DOI: 10.1016/j.bioelechem.2021.107831

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