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Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas

16 Jun 2025

Abstract excerpt

A major challenge hampering therapeutic advancements for high-risk sarcoma patients is the broad spectrum of molecularly distinct sarcoma types and the corresponding lack of suitable model systems. Here we describe the development of a genetically-controlled, yet versatile mouse modeling platform allowing delivery of different genetic lesions by muscle electroporation (EPO) in wildtype mice. This EPO-GEMM...

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PMID: 40523919
DOI: 10.1038/s41467-025-60519-5

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