Article

Cardiomyocyte Contractile Impairment in Heart Failure Results from Reduced BAG3-mediated Sarcomeric Protein Turnover

2020-04-12

Abstract excerpt

<h4>ABSTRACT</h4> The association between reduced myofilament force-generating capacity (F max ) and heart failure (HF) is clear, however the underlying molecular mechanisms are poorly understood. Here, we show the F max decrease arises from impaired BAG3-mediated sarcomere turnover. Myofilament BAG3 decreased in human HF and predicted the extent of F max decrease. This relationship was confirmed using BAG3 +...

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Literature Corpus work: 3679ec8c-3507-5255-8f58-f9f3b1f2f5f7
DOI: 10.1101/2020.04.10.022319

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