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Breast Cancer-Related Low Penetrance Genes.

Advances in experimental medicine and biology - 1 Jan 2021

Kang Daehee, Choi Ji-Yeob

Abstract excerpt

Susceptibility genes involved in disease etiology and prognosis are categorized into two groups: high penetrance genes (i.e., BRCA1, CHEK2, ATM, etc.) and low penetrance genes (i.e., NATs, GSTs, CYPs, etc., and variants identified by genome-wide association studies). Since low penetrance genes have high population attributable risk, the usefulness of those genes to research on breast cancer prevention is not...

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PMID: 33983592
DOI: 10.1007/978-981-32-9620-6_22

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