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BRCA and Breast Cancer-Related High-Penetrance Genes.

Advances in experimental medicine and biology - 1 Jan 2021

Han Sang-Ah, Kim Sung-Won

Abstract excerpt

Genetic susceptibility explains 5-10% of all breast cancer cases. High-penetrance breast cancer susceptibility genes deliberate a greater than tenfold relative risk of breast cancer. BRCA1 and BRCA2 genes are the most common cause of hereditary breast cancer, and TP53, PTEN, and SKT11 (LKB1) are rarely present. The prevalence of BRCA1 and BRCA2 genetic alterations differ in various ethnic groups. The Korean...

Topics

Breast Neoplasms
Female
Genes, BRCA2
Genetic Predisposition to Disease
Humans
Mutation
Ovarian Neoplasms
Penetrance
Republic of Korea

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33983595
DOI: 10.1007/978-981-32-9620-6_25

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