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Article

Penetrance of male breast cancer susceptibility genes: a systematic review.

Breast cancer research and treatment - 1 Jan 2022

Chamseddine Reem S, Wang Cathy, Yin Kanhua, Wang Jin, Singh Preeti, Zhou Jingan, Robson Mark E, Braun Danielle, Hughes Kevin S

Abstract excerpt

PURPOSE: Several male breast cancer (MBC) susceptibility genes have been identified, but the MBC risk for individuals with a pathogenic variant in each of these genes (i.e., penetrance) remains unclear. We conducted a systematic review of studies reporting the penetrance of MBC susceptibility genes to better summarize current estimates of penetrance. METHODS: A search query was developed to identify MBC-related...

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PMID: 34642874
DOI: 10.1007/s10549-021-06413-2

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