Article
Clinical implications of low-penetrance breast cancer susceptibility alleles.
Current oncology reports - 1 Jan 2009
Freisinger Francis, Domchek Susan M
Abstract excerpt
Our understanding of breast cancer genetics is evolving beyond deleterious mutations in BRCA1 and BRCA2. In the past several years, several low- and moderate-risk breast cancer susceptibility alleles have been identified that have a relative risk for breast cancer of < or = 2. The availability of new techniques such as genome-wide association studies ensures that more low-risk alleles will be identified. This...
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