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The mouse-lethal H5N1 influenza virus carrying the PB2-384L/443R/460M characteristics acquired in avian hosts can effectively utilize human ANP32A/B proteins.

Emerging microbes & infections - 1 Dec 2026

Lin Weipeng, Deng Guohua, Xing Xin, Shi Jianzhong, Kong Huihui, Liu Liling, Zeng Xianying, Jiang Li, Li Chengjun, Guan Yuntao, Cui Pengfei, Chen Hualan

Abstract excerpt

The species-specific acidic nuclear phosphoprotein 32 kDa members (ANP32A/B) play a key role in restricting the function of avian influenza virus polymerase in mammalian host. Avian influenza viruses, upon replicating in humans, may acquire critical amino acid substitutions in the polymerase basic 2 (PB2) protein (e.g. E627 K and D701N) that enhance the viral polymerase's functional compatibility with human...

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Identifiers

PMID: 42246480
DOI: 10.1080/22221751.2026.2685917
PMCID: PMC13288910

Genes

ANP32A
ANP32B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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