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Article

Whole-exome sequencing reveals genetic variations in humans with differential sensitivity to sevoflurane：A prospective observational study.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Apr 2022

Wei Yiyong, Zhang Donghang, Zuo Yunxia

Abstract excerpt

BACKGROUND: The anesthesia sensitivity is heterogeneous both in animals and humans, while the underlying molecular mechanism has not yet been determined. Here, for the first time, we conducted a prospective observational study to test whether genetic variations contribute to the differential sensitivity to sevoflurane in humans. METHODS: Five hundred patients who underwent abdominal surgeries were included. The...

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Identifiers

PMID: 35202912
DOI: 10.1016/j.biopha.2022.112724

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