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Article

Clinical pharmacology and pharmacogenetics of gemcitabine

1 May 2009

Abstract excerpt

Gemcitabine is a cytotoxic nucleoside analog, which is widely used in the treatment of malignancies. Interindividual differences in gemcitabine pharmacokinetics and pharmacodynamics have been demonstrated. Pharmacogenetic factors may account for a significant proportion of these differences. This review provides an update on the pharmacogenetics of gemcitabine and its influence on gemcitabine efficacy and toxicity.

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Identifiers

PMID: 19514966
DOI: 10.1080/03602530902741828

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