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CDH18 is a fetal epicardial biomarker regulating differentiation towards vascular smooth muscle cells

2 Feb 2022

Abstract excerpt

The epicardium is a mesothelial layer covering the myocardium serving as a progenitor source during cardiac development. The epicardium reactivates upon cardiac injury supporting cardiac repair and regeneration. Fine-tuned balanced signaling regulates cell plasticity and cell-fate decisions of epicardial-derived cells (EPCDs) via epicardial-to-mesenchymal transition (EMT). However, powerful tools to investigate...

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PMID: 35110584
DOI: 10.1038/s41536-022-00207-w

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