Article
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
American journal of human genetics - 1 Apr 2009
Tanaka Toshiko, Scheet Paul, Giusti Betti, Bandinelli Stefania, Piras Maria Grazia, Usala Gianluca, Lai Sandra, Mulas Antonella, Corsi Anna Maria, Vestrini Anna, Sofi Francesco, Gori Anna Maria, Abbate Rosanna, Guralnik Jack, Singleton Andrew, Abecasis Goncalo R, Schlessinger David, Uda Manuela, Ferrucci Luigi
Abstract excerpt
The B vitamins are components of one-carbon metabolism (OCM) that contribute to DNA synthesis and methylation. Homocysteine, a by-product of OCM, has been associated with coronary heart disease, stroke and neurological disease. To investigate genetic factors that affect circulating vitamin B6, vitamin B12, folate and homocysteine, a genome-wide association analysis was conducted in the InCHIANTI (N = 1175),...
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