Article
Association of IL-10 (- 1082 A/G) and IL-6 (- 174 G/C) gene polymorphism with type 2 diabetes mellitus in Ethiopia population.
BMC endocrine disorders - 15 Apr 2021
Ayelign Birhanu, Negash Markos, Andualem Henok, Wondemagegn Tadelo, Kassa Eyuel, Shibabaw Tewodros, Akalu Yonas, Molla Meseret Derbew
Abstract excerpt
BACKGROUND: Interleukin (IL)-6 and IL-10 are the most important cytokine with pro and anti-inflammatory activities, respectively. Dysregulation of IL-6 and IL-10 are associated with increased risk of developing Type 2 Diabetes Mellitus (T2DM). Despite this, a fundamental understanding of both cytokine gene polymorphisms with its expression is critical in understanding of cellular mechanism of insulin resistance...
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