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Bone Cells Differentiation: How CFTR Mutations May Rule the Game of Stem Cells Commitment?

7 May 2021

Abstract excerpt

Cystic fibrosis (CF)-related bone disease has emerged as a significant comorbidity of CF and is characterized by decreased bone formation and increased bone resorption. Both osteoblast and osteoclast differentiations are impacted by cystic fibrosis transmembrane conductance regulator (CFTR) mutations. The defect of CFTR chloride channel or the loss of CFTRs ability to interact with other proteins affect several...

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PMID: 34026749
DOI: 10.3389/fcell.2021.611921

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