Article
Chd7 Is Critical for Early T-Cell Development and Thymus Organogenesis in Zebrafish.
The American journal of pathology - 1 Apr 2018
Liu Zhi-Zhi, Wang Zi-Long, Choi Tae-Ik, Huang Wen-Ting, Wang Han-Tsing, Han Ying-Ying, Zhu Lou-Yin, Kim Hyun-Taek, Choi Jung-Hwa, Lee Jin-Soo, Kim Hyung-Goo, Zhao Jian, Chen Yue, Lu Zhuo, Tian Xiao-Li, Pan Bing-Xing, Li Bao-Ming, Kim Cheol-Hee, Xu Hong A
Abstract excerpt
Coloboma, heart defect, atresia choanae, retarded growth and development, genital hypoplasia, ear anomalies/deafness (CHARGE) syndrome is a congenital disorder affecting multiple organs and mainly caused by mutations in CHD7, a gene encoding a chromatin-remodeling protein. Immunodeficiency and reduced T cells have been noted in CHARGE syndrome. However, the mechanisms underlying T lymphopenia are largely...
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