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Article

Effects of genetic polymorphisms on the sulfation of doxorubicin by human SULT1C4 allozymes.

Journal of biochemistry - 12 Oct 2021

Gohal Saud A, Rasool Mohammed I, Bairam Ahsan F, Alatwi Eid S, Alherz Fatemah A, Abunnaja Maryam S, El Daibani Amal A, Kurogi Katsuhisa, Liu Ming-Cheh

Abstract excerpt

Doxorubicin is a chemotherapeutic drug widely utilized in cancer treatment. An enzyme critical to doxorubicin metabolism is the cytosolic sulfotransferase (SULT) SULT1C4. This study investigated the functional impact of SULT1C4 single nucleotide polymorphisms (SNPs) on the sulfation of doxorubicin by SULT1C4 allozymes. A comprehensive database search was performed to identify various SULT1C4 SNPs. Ten...

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Identifiers

PMID: 33950190
DOI: 10.1093/jb/mvab055
PMCID: PMC8510289

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