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Article

Host Chromatin Regulators Required for Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Activity in Saccharomyces cerevisiae Model.

Infection and immunity - 15 Jul 2021

Denmongkholchai Siriyod, Tsuruda Keiko, Sugai Motoyuki, Mongkolsuk Skorn, Matangkasombut Oranart

Abstract excerpt

Cytolethal distending toxin (CDT) is a bacterial genotoxin that causes host cell cycle arrest and death. We previously employed a Saccharomyces cerevisiae model with inducible expression of the CDT catalytic subunit from Aggregatibacter actinomycetemcomitans, AaCdtB, and showed that a wide variety of host factors play a role in facilitating the activity of CdtB. Our observation that a yeast H2B mutant defective...

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Identifiers

PMID: 33941581
DOI: 10.1128/IAI.00036-21
PMCID: PMC8281284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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