Article
A Cytolethal Distending Toxin Variant from Aggregatibacter actinomycetemcomitans with an Aberrant CdtB That Lacks the Conserved Catalytic Histidine 160.
PloS one - 1 Jan 2016
Obradović Davor, Gašperšič Rok, Caserman Simon, Leonardi Adrijana, Jamnik Maja, Podlesek Zdravko, Seme Katja, Anderluh Gregor, Križaj Igor, Maček Peter, Butala Matej
Abstract excerpt
The periodontopathogen Aggregatibacter actinomycetemcomitans synthesizes several virulence factors, including cytolethal distending toxin (CDT). The active CDT holoenzyme is an AB-type tripartite genotoxin that affects eukaryotic cells. Subunits CdtA and CdtC (B-components) allow binding and intracellular translocation of the active CdtB (A-component), which elicits nuclear DNA damage. Different strains of A....
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