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Truncated Tau caused by intron retention is enriched in Alzheimer’s disease cortex and exhibits altered biochemical properties

6 Sept 2022

Abstract excerpt

Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β plaques and Tau tangles in brain tissues. Recent studies indicate that aberrant splicing and increased level of intron retention is linked to AD pathogenesis. Bioinformatic analysis revealed increased retention of intron 11 at the Tau gene in AD female dorsal lateral prefrontal cortex as compared to healthy controls, an observation...

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PMID: 36067305
DOI: 10.1073/pnas.2204179119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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