Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21

Abstract excerpt

BACKGROUND: Down syndrome (DS) is caused by trisomy 21 (+21), but the aberrations in gene expression resulting from this chromosomal aneuploidy are not yet completely understood. METHODS: We used oligonucleotide microarrays to survey mRNA expression in early- and late-passage control and +21 fibroblasts and mid-gestation fetal hearts. We supplemented this analysis with northern blotting, western blotting,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Down syndrome and intellectual disability research
• Share to Genomic variations and chromosomal abnormalities
• Share to Immunodeficiency and Autoimmune Disorders