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Article

GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function.

Molecular cancer research : MCR - 1 Nov 2024

Ray Paramita, Jaiswal Sangeeta, Ferrer-Torres Daysha, Wang Zhuwen, Nancarrow Derek, Curtin Meghan, Martinho May San, Lacy Shannon M, Kasturirangan Srimathi, Thomas Dafydd, Spence Jason R, Truttmann Matthias C, Lagisetty Kiran H, Lawrence Theodore S, Wang Thomas D, Beer David G, Ray Dipankar

Abstract excerpt

Frequent (>70%) TP53 mutations often promote its protein stabilization, driving esophageal adenocarcinoma (EAC) development linked to poor survival and therapy resistance. We previously reported that during Barrett's esophagus progression to EAC, an isoform switch occurs in the E3 ubiquitin ligase RNF128 (aka GRAIL-gene related to anergy in lymphocytes), enriching isoform 1 (hereby GRAIL1) and stabilizing the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39018356
DOI: 10.1158/1541-7786.MCR-24-0361
PMCID: PMC11530312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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