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Article

Gestational sleep apnea perturbations induce metabolic disorders by divergent epigenomic regulation.

Epigenomics - 1 May 2021

Cortese Rene, Khalyfa Abdelnaby, Bao Riyue, Gozal David

Abstract excerpt

Aim: Late-gestational sleep fragmentation (LG-SF) and intermittent hypoxia (LG-IH), two hallmarks of obstructive sleep apnea, lead to metabolic dysfunction in the offspring. We investigated specific biological processes that are epigenetically regulated by LG-SF and LG-IH. Materials & methods: We analyzed DNA methylation profiles in offspring visceral white adipose tissues by MeDIP-chip followed by pathway...

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PMID: 33929266
DOI: 10.2217/epi-2020-0435

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