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Gestational Intermittent Hypoxia Enhances Mammary Stem Cells and Alters Tumor Phenotype in Adult Female Offspring.

Cells - 29 Jan 2024

Joshi Jaitri, Xiong Yue, Kuhn Molly, Radcliff Abigail B, Baker Tracy L, Watters Jyoti J, Arendt Lisa M

Abstract excerpt

An adverse perinatal environment can increase long-term cancer risk, although the precise nature of associated perinatal triggers remain unknown. Sleep apnea is a common condition during pregnancy, characterized by recurrent cessations in breathing during sleep, and the potential consequences of sleep apnea during pregnancy as it relates to breast cancer risk in offspring have not been explored. To model sleep...

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PMID: 38334641
DOI: 10.3390/cells13030249
PMCID: PMC10854849

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