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Article

The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects.

Brain : a journal of neurology - 1 Dec 2020

Smith Ruben, Strandberg Olof, Mattsson-Carlgren Niklas, Leuzy Antoine, Palmqvist Sebastian, Pontecorvo Michael J, Devous Michael D, Ossenkoppele Rik, Hansson Oskar

Abstract excerpt

The development of tau-PET allows paired helical filament tau pathology to be visualized in vivo. Increased knowledge about conditions affecting the rate of tau accumulation could guide the development of therapies halting the progression of Alzheimer's disease. However, the factors modifying the rate of tau accumulation over time in Alzheimer's disease are still largely unknown. Large-scale longitudinal cohort...

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Identifiers

PMID: 33439987
DOI: 10.1093/brain/awaa327
PMCID: PMC7805812

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