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Article

HLA-A*24:07 as a potential biomarker for carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Filipino patients.

Pharmacogenomics - 1 Jun 2021

Capule Francis, Tragulpiankit Pramote, Mahasirimongkol Surakameth, Jittikoon Jiraphun, Wichukchinda Nuanjun, Alentajan-Aleta Lara Theresa, Barit Jay-V James, Casanova-Gutierrez Josephine, Cabral-Lim Leonor, Baltazar Reyes Jose Paciano, Roa Francisca, Salonga Raymark, San Gabriel Katrina Faith, Silao Catherine Lynn

Abstract excerpt

Aim: A case-control study was conducted in Filipino patients to determine the association between HLA alleles and carbamazepine-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Materials & methods: A retrospective review of medical records and data collection were performed. A total of 10 carbamazepine-induced SJS/TEN cases and 40 tolerant controls were recruited. Genomic DNA extracted...

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Identifiers

PMID: 33910375
DOI: 10.2217/pgs-2020-0191
PMCID: PMC8191649

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