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Article

Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design.

Pharmacogenetics and genomics - 1 Jun 2021

Stone Isabella B, Green Jessica A E M, Koefoed Andrew W, Hornik Ezra S, Williams Jonathan S, Adler Gail K, Williams Gordon H

Abstract excerpt

OBJECTIVES: In human studies and genetically altered mouse studies, variants in the striatin gene (STRN) are associated with increased blood pressure (BP) and aldosterone on a liberal salt diet. This clinical trial is based on the presumed mechanism for striatin-associated HTN - increased aldosterone. It is designed to determine if participants with the STRN risk alleles will have a greater BP reduction on a...

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Identifiers

PMID: 33904521
DOI: 10.1097/FPC.0000000000000425
PMCID: PMC10352129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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