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Article

The essential role of intraflagellar transport protein IFT81 in male mice spermiogenesis and fertility

1 Apr 2020

Abstract excerpt

Intraflagellar transport (IFT) is an evolutionarily conserved mechanism that is indispensable for the formation and maintenance of cilia and flagella; however, the implications and functions of IFT81 remain unknown. In this study, we disrupted IFT81 expression in male germ cells starting from the spermatocyte stage. As a result, homozygous mutant males were completely infertile and displayed abnormal sperm...

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PMID: 32233951
DOI: 10.1152/ajpcell.00450.2019

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