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Article

A Mendelian randomization study of the role of lipoprotein subfractions in coronary artery disease.

eLife - 26 Apr 2021

Zhao Qingyuan, Wang Jingshu, Miao Zhen, Zhang Nancy R, Hennessy Sean, Small Dylan S, Rader Daniel J

Abstract excerpt

Recent genetic data can offer important insights into the roles of lipoprotein subfractions and particle sizes in preventing coronary artery disease (CAD), as previous observational studies have often reported conflicting results. We used the LD score regression to estimate the genetic correlation of 77 subfraction traits with traditional lipid profile and identified 27 traits that may represent distinct genetic...

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Identifiers

PMID: 33899735
DOI: 10.7554/eLife.58361
PMCID: PMC8163505

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