Article
High-density lipoprotein characteristics and coronary artery disease: a Mendelian randomization study.
Metabolism: clinical and experimental - 1 Nov 2020
Prats-Uribe Albert, Sayols-Baixeras Sergi, Fernández-Sanlés Alba, Subirana Isaac, Carreras-Torres Robert, Vilahur Gemma, Civeira Fernando, Marrugat Jaume, Fitó Montserrat, Hernáez Álvaro, Elosua Roberto
Abstract excerpt
BACKGROUND: To assess whether genetically determined quantitative and qualitative HDL characteristics were independently associated with coronary artery disease (CAD). METHODS: We designed a two-sample multivariate Mendelian randomization study with available genome-wide association summary data. We identified genetic variants associated with HDL cholesterol and apolipoprotein A-I levels, HDL size, particle...
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