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The role of glycans in the mechanobiology of cancer

21 Jan 2023

Abstract excerpt

Although cancer is a genetic disease, physical changes such as stiffening of the extracellular matrix also commonly occur in cancer. Cancer cells sense and respond to extracellular matrix stiffening through the process of mechanotransduction. Cancer cell mechanotransduction can enhance cancer-promoting cell behaviors such as survival signaling, proliferation, and migration. Glycans, carbohydrate-based polymers,...

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PMID: 36693448
DOI: 10.1016/j.jbc.2023.102935

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