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Article

The atypical binding mechanism of second calcium on phospholipase A2 group IIE.

Biochemical and biophysical research communications - 11 Jun 2021

Hou Shulin, Bai Junping, Chen Chunting, Zhang Xiaozheng, Chang Fangyuan, Cao Zhihua, Xu Tingting, Xie Jun

Abstract excerpt

Secreted phospholipase A2s (sPLA2s) are calcium dependent enzymes involved in various biological events such as lipid metabolism and inflammation. We previously identified the second calcium (Ca2) binding site of human sPLA2 Group IIE (hGIIE) by structural study and suggested that Asn21 act as the switch of Ca2 binding to modulate the enzymatic activity, but the detailed Ca2 binding mechanism is still unclear....

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PMID: 33894413
DOI: 10.1016/j.bbrc.2021.04.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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