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Article

RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.

Journal of neurochemistry - 1 Jul 2021

Shumate Kayla M, Tas Sadik T, Kavalali Ege T, Emeson Ronald B

Abstract excerpt

Calcium-dependent activator protein for secretion 1 (CAPS1) is a SNARE accessory protein that facilitates formation of the SNARE complex to enable neurotransmitter release. Messenger RNAs encoding CAPS1 are subject to a site-specific adenosine-to-inosine (A-to-I) editing event resulting in a glutamate-to-glycine (E-to-G) substitution in the C-terminal domain of the encoded protein product. The C-terminal domain...

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Identifiers

PMID: 33894004
DOI: 10.1111/jnc.15372
PMCID: PMC8282701

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