Article

RNA-targeted therapy corrects neuronal deficits in PACS1 syndrome mice

2023-01-27

Abstract excerpt

<title>Abstract</title> <p>Neurodevelopmental disorders (NDDs) are frequently associated with dendritic abnormalities in pyramidal neurons that affect arbor complexity, spine density, and synaptic communication 1,2. The underlying genetic causes are often complex, obscuring the molecular pathways that drive these disorders 3. Next-generation sequencing has identified recurrent de novo missense mutations in a hand...

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Literature Corpus work: 7f9cfda1-83ba-5e17-a9a3-b8efc573274d
DOI: 10.21203/rs.3.rs-2440581/v1

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