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Article

Activated IL-6 signaling contributes to the pathogenesis of, and is a novel therapeutic target for, CALR-mutated MPNs.

Blood advances - 27 Apr 2021

Balliu Manjola, Calabresi Laura, Bartalucci Niccolò, Romagnoli Simone, Maggi Laura, Manfredini Rossella, Lulli Matteo, Guglielmelli Paola, Vannucchi Alessandro Maria

Abstract excerpt

Calreticulin (CALR), an endoplasmic reticulum-associated chaperone, is frequently mutated in myeloproliferative neoplasms (MPNs). Mutated CALR promotes downstream JAK2/STAT5 signaling through interaction with, and activation of, the thrombopoietin receptor (MPL). Here, we provide evidence of a novel mechanism contributing to CALR-mutated MPNs, represented by abnormal activation of the interleukin 6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33890979
DOI: 10.1182/bloodadvances.2020003291
PMCID: PMC8095134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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