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Article

Functional Analyses of Transcription Factor Binding Sites that Differ between Present-Day and Archaic Humans.

Molecular biology and evolution - 1 Feb 2016

Weyer Sven, Pääbo Svante

Abstract excerpt

We analyze 25 previously identified transcription factor binding sites that carry DNA sequence changes that are present in all or nearly all present-day humans, yet occur in the ancestral state in Neandertals and Denisovans, the closest evolutionary relatives of humans. When the ancestral and derived forms of the transcription factor binding sites are tested using reporter constructs in 3 neuronal cell lines, the...

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Identifiers

PMID: 26454764
DOI: 10.1093/molbev/msv215
PMCID: PMC4866544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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