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Article

Distal lysine (de)coordination in the algal hemoglobin THB1: A combined computer simulation and experimental study.

Journal of inorganic biochemistry - 1 Jul 2021

Julió Plana Laia, Martinez Grundman Jaime E, Estrin Darío A, Lecomte Juliette T J, Capece Luciana

Abstract excerpt

THB1 is a monomeric truncated hemoglobin from the green alga Chlamydomonas reinhardtii. In the absence of exogenous ligands and at neutral pH, the heme group of THB1 is coordinated by two protein residues, Lys53 and His77. THB1 is thought to function as a nitric oxide dioxygenase, and the distal binding of O2 requires the cleavage of the Fe-Lys53 bond accompanied by protonation and expulsion of the lysine from...

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Identifiers

PMID: 33882423
DOI: 10.1016/j.jinorgbio.2021.111455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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