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Article

Flavodiiron oxygen reductase from Entamoeba histolytica: modulation of substrate preference by tyrosine 271 and lysine 53.

The Journal of biological chemistry - 10 Oct 2014

Gonçalves Vera L, Vicente João B, Pinto Liliana, Romão Célia V, Frazão Carlos, Sarti Paolo, Giuffrè Alessandro, Teixeira Miguel

Abstract excerpt

Flavodiiron proteins (FDPs) are a family of enzymes endowed with bona fide oxygen- and/or nitric-oxide reductase activity, although their substrate specificity determinants remain elusive. After a comprehensive comparison of available three-dimensional structures, particularly of FDPs with a clear preference toward either O2 or NO, two main differences were identified near the diiron active site, which led to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25151360
DOI: 10.1074/jbc.M114.579086
PMCID: PMC4192481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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