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Bufadienolides from the Eggs of the Toad Bufo bufo gargarizans and Their Antimelanoma Activities

21 Apr 2021

Abstract excerpt

Toads produce potent toxins, named bufadienolides, to defend against their predators. Pharmacological research has revealed that bufadienolides are potential anticancer drugs. In this research, we reported nine bufadienolides from the eggs of the toad Bufo bufo gargarizans, including two new compounds ( 1 and 3 ). The chemical structures of 1 and 3, as well as of one previously reported semisynthesized compound (...

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PMID: 33882233
DOI: 10.1021/acs.jnatprod.0c00840

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