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Article

Developmental toxicity caused by sanguinarine in zebrafish embryos via regulating oxidative stress, apoptosis and wnt pathways.

Toxicology letters - 10 Oct 2021

Yang Xueliang, Wang Xue, Gao Daili, Zhang Yun, Chen Xiqiang, Xia Qing, Jin Meng, Sun Chen, He Qiuxia, Wang Rongchun, Liu Kechun

Abstract excerpt

Sanguinarine, derived from the root of Sanguinaria canadensis, have multiple biological activities, such as antimicrobial, insecticidal, antitumor, anti-inflammatory and anti-angiogenesis effect, but little is known about its toxicity on normal embryonic development. Here, we study the developmental toxicity using zebrafish model. Notably, sanguinarine caused a significant increase of the malformation rate and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34252508
DOI: 10.1016/j.toxlet.2021.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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