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Syntheses of Fumagillin and Ovalicin

5 Mar 2010

Abstract excerpt

This review focuses on the synthetic strategies used for the construction of fumagillin, ovalicin, and other natural products of this family that are known angiogenesis inhibitors. These compounds are comprised of a cyclohexane framework, two epoxides, and five or six contiguous stereogenic centers. The first total syntheses of fumagillin and ovalicin were reported by Corey in 1972 and 1985, respectively. There...

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PMID: 20209516
DOI: 10.1002/chem.200902433

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