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Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021

9 Dec 2014

Abstract excerpt

Eight new chromones, engyodontiumones A-H (1-8), and three new phenol derivatives (9-11) together with eight known polyketides (12-19) were isolated from the deep-sea-derived fungus Engyodontium album DFFSCS021. Their structures were identified by extensive spectroscopic analysis. Compounds 8 and 16 showed significant selective cytotoxicity against human histiocytic lymphoma U937 cell line with IC50 values of 4.9...

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PMID: 25501793
DOI: 10.3390/md12125902

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