Bufalin inhibits cytokine storm by regulating TLR4/TLR3 signaling pathway.

Abstract excerpt

Bufalin is one main component of the dried venom from Bufo gargarizans Cantor . Bufalin has anti-tumor, cardiotonic, anti-inflammatory and other physiological activities. However, in recent years, researchers have mainly paid attention to its anti-tumor effect and neglected its anti-inflammatory effect. We used lipopolysaccharide (TLR4 ligand) and poly inosinic acid (TLR3 ligand) to stimulate cultured macrophages...

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• Bee Products Chemical Analysis
• Bioactive Compounds and Antitumor Agents
• Cytokine Signaling Pathways and Interactions
• Healthcare and Venom Research
• Neurobiology and Insect Physiology Research
• NF-κB Signaling Pathways
• Phytochemicals and Medicinal Plants
• Venomous Animal Envenomation and Studies

Identifiers and source

Literature Corpus work

23017dc8-c85f-5830-bd90-a056a7356ad5

DOI

10.22541/au.173925755.56202203/v1