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Article

DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice

4 Feb 2021

Abstract excerpt

Abstract The outbreak of the SARS-CoV-2 virus and its rapid spread into a global pandemic made the urgent development of scalable vaccines to prevent coronavirus disease (COVID-19) a global health and economic imperative. Here, we characterized and compared the immunogenicity of two alphavirus-based DNA-launched self-replicating (DREP) vaccine candidates encoding either SARS-CoV-2 spike glycoprotein (DREP-S) or a...

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PMID: 33542325
DOI: 10.1038/s41598-021-82498-5

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