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Scalable, high quality, whole genome sequencing from archived, newborn, dried blood spots

14 Feb 2023

Abstract excerpt

Universal newborn screening (NBS) is a highly successful public health intervention. Archived dried bloodspots (DBS) collected for NBS represent a rich resource for population genomic studies. To fully harness this resource in such studies, DBS must yield high-quality genomic DNA (gDNA) for whole genome sequencing (WGS). In this pilot study, we hypothesized that gDNA of sufficient quality and quantity for WGS...

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PMID: 36788231
DOI: 10.1038/s41525-023-00349-w

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