Assessing quality and functionality of DNA from fresh and archival dried blood spots and recommendations for quality control guidelines.

doi:10.1373/clinchem.2007.087510

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Article

Assessing quality and functionality of DNA from fresh and archival dried blood spots and recommendations for quality control guidelines.

Clinical chemistry - 1 Aug 2007

Sjöholm Malin Ida Linnea, Dillner Joakim, Carlson Joyce

Abstract excerpt

BACKGROUND: Dried blood spots (DBS) are a convenient and inexpensive method for biobanking. Although many countries have established population-based DBS biobanks from neonatal screening programs, the quality and usefulness of DNA from DBS have not been extensively assessed. METHODS: We compared 4 common DNA extraction methods (Qiagen, EZNA, Chelex 100, and alkaline lysis) in a pilot study using fresh DBS with...

Topics

Blood Banks
Blood Specimen Collection
DNA
Humans
Infant, Newborn
Neonatal Screening
Pilot Projects
Polymorphism, Single Nucleotide
Practice Guidelines as Topic
Quality Control
Temperature
Time Factors

Source

Open in PubMed

Identifiers

PMID: 17586590
DOI: 10.1373/clinchem.2007.087510

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