Article
Genome-wide scans using archived neonatal dried blood spot samples.
BMC genomics - 4 Jul 2009
Hollegaard Mads V, Grauholm Jonas, Børglum Anders, Nyegaard Mette, Nørgaard-Pedersen Bent, Ørntoft Torben, Mortensen Preben B, Wiuf Carsten, Mors Ole, Didriksen Michael, Thorsen Poul, Hougaard David M
Abstract excerpt
BACKGROUND: Identification of disease susceptible genes requires access to DNA from numerous well-characterised subjects. Archived residual dried blood spot samples from national newborn screening programs may provide DNA from entire populations and medical registries the corresponding clinical information. The amount of DNA available in these samples is however rarely sufficient for reliable genome-wide scans,...
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