Article
DPYD c.1905 + 1G>A Promotes Fluoropyrimidine-Induced Anemia, a Prognostic Factor in Disease-Free Survival, in Colorectal Cancer.
Genetic testing and molecular biomarkers - 1 Apr 2021
Deligonul Adem, Aksoy Secil, Tezcan Gulcin, Tunca Berrin, Kanat Ozkan, Cubukcu Erdem, Yilmazlar Tuncay, Ozturk Ersin, Egeli Unal, Cecener Gulsah, Alemdar Adem, Evrensel Turkkan
Abstract excerpt
Background and Aim: In 10-30% of colorectal cancer (CRC) patients, toxic reactions occur after fluoropyrimidine-based chemotherapy. A dihydropyridine dehydrogenase (DPYD) gene variant, c.1905 + 1G>A, leads to intolerance to fluoropyrimidines. Due to the low frequency of this variant in many populations, the prevalence of fluoropyrimidine-induced hematologic side effects in CRC patients with the c.1905 + 1G>A...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.