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Article

Predictive value of clinical toxicities of chemotherapy with fluoropyrimidines and oxaliplatin in colorectal cancer by DPYD and GSTP1 gene polymorphisms.

World journal of surgical oncology - 6 Dec 2020

Deng Xunwei, Hou Jingyuan, Deng Qiaoting, Zhong Zhixiong

Abstract excerpt

BACKGROUND: Fluoropyrimidines and platinum are still widely used for colorectal cancer (CRC) management. Several studies have reported that mutations of dihydropyrimidine dehydrogenase (DPYD) and glutathione S-transferase pi-1 (GSTP1) polymorphisms are related to chemotherapy-related adverse events. In the present study, we purposed to assess the impact of DPYD and GSTP1 variants on the toxicity of adjuvant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33280607
DOI: 10.1186/s12957-020-02103-3
PMCID: PMC7720377

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